CTCF es una proteína arquitectónica que organiza el genoma dentro del núcleo en casi todas las células eucariotas. Hay evidencias que sugieren el papel clave que CTCF tiene durante la espermatogénesis donde su eliminación da como resultado la producción anormal de espermatozoides e infertilidad en un modelo murino. Sin embargo,...
Osteosarcopenic obesity (OSO) has been associated with immobility, falls, fractures, and other dysfunctions, which could increase mortality risk. However, its etiology remains unknown. Recent studies revealed that sedentarism, fat gain, and epigenetic regulators are critical in its development. One effective intervention to prevent and treat OSO is exercise. Therefore, in...
Capacitation is a set of biochemical and physiological changes that occur in spermatozoa during their transit along the female reproductive tract that are necessary to become cells able to fertilize the female gamete. Although several mechanisms related to capacitation have been studied, such as the increase of tyrosine phosphorylation, there...
The objective of this work was to determine the association between miRNAs and the differentiation process of satellite cells (SC) during Duchenne and Becker muscular dystrophy. Using expression microarrays, it was found that 15 miRNAs (miR-1-2, miR-184, miR-130a, miR-106b, miR-155, miR-153-1, let-7f-2, miR-130b, let -7e, miR-141, miR-20, miR-133a-1 miR-19a, miR-183,...
El carcinoma hepatocelular (HCC) constituye la cuarta causa de muerte relacionada con cáncer a nivel mundial y la tasa de incidencia de este continúa en ascenso, tanto en hombres como en mujeres. La principal causa ha sido el consumo de dietas hipercalóricas ricas en carbohidratos como la fructosa. La dieta...
La exposición a contaminantes ambientales como los metales pesados, afectan a la salud reproductiva del ser humano. El cadmio (Cd), es un metal pesado ampliamente utilizado en las industrias, lo que facilita su incorporación al medio ambiente y a la cadena alimenticia. La exposición ocupacional y ambiental a este metal...
La deficiencia de hormonas tiroideas al nacimiento es conocido como hipotiroidismo congénito(HC), esta patología puede alterar algunas funciones reproductivas interviniendo en el proceso de espermatogénesis desde etapas tempranas como lo es la diferenciación de gonocitos, lo que podría repercutir en la etapa juvenil y por lo tanto en la fertilidad...
Controlled ovarian stimulation is based on the recruitment of several follicles at the beginning of each menstrual cycle, through the administration of agonists of Gonadotropin-releasing hormone (GnRH), recombinant follicle-stimulating hormone (FSHr), human menopausal gonadotropin hormone (hMG) and human chorionic gonadotropin hormone (hCG). In the course of a natural ovarian cycle,...
Rheumatoid arthritis (RA) is a chronic, inflammatory and autoimmune disease of multifactorial etiology that mainly affects women. Various environmental and genetic factors contribute to its development. Some genes that code proteins and that regulate the immune system have been associated with susceptibility to RA. One of them is the VEGF-A...