El cáncer cervicouterino (CaCu) es el segundo cáncer más común en el mundo que ocurre en la población femenina. La mayoría de los casos de CaCu se diagnostican en estadios avanzados. Por lo tanto, la radioterapia es la modalidad terapéutica más utilizada. El mecanismo de acción de la radiación ionizante...
Loss of function of the p53 tumor suppressor due to mutations causes genomic instability in cancer cells. Mutations of p53, which occur in more than 50% of all human cancers, are characterized by a gain of oncogenic function and loss of wildtype p53 function in cancer cells. Centrosome amplification is...
Chronic kidney disease (CKD) is a global health problem that affects around 850 million people in the world. CKD is associated with the development of cardiac alterations that increase in more than 50% risk of mortality. In a previous study, it was demonstrated that during CKD progression, cardiac alterations including...
Cervical cancer (CaCu) is a serious public health problem, being the second cause of death in women from cancer in Mexico. One of the main drugs used in chemotherapy against CaCu is cisplatin; however, it has the disadvantages of high toxicity in patients and some cases it usually generates chemoresistance....