Excitotoxicity occurs in response to the overactivation of glutamate receptors. Excitotoxicity is involved in neurodegenerative diseases and in acute brain diseases, such as brain injury and stroke. Glutamatergic signaling during excitotoxicity initiates with the loss of Ca2+ homeostasis that promotes, among other events, the overproduction of reactive oxygen species (ROS)...
Some individuals show resistance to diseases and disorders even under adverse conditions (resilience), and others are more susceptible to them (vulnerability). Modifying litter size is a common method to study obesity and malnutrition, and its effects. Previous studies in our laboratory suggested that litter size negatively impacts sexual behavior, memory,...