Gestodene (GSD; 13p-ethyl-I 7a-ethynyl-l7p-hydroxy-4,15-gonadien-3-one) is the most potent synthetic progestin currently available and it is widely used as a fertility regulating agent in a number of contraceptive formulations because of its high effectiveness, safety and acceptability. The observations that this contraceptive synthetic progestin exerts estrogen-like effects besides that of its...