Active caspases 3- and -7 are considered key in somatic and testicular germ cell apoptosis signalization. Strategies of in situ or ex situ label permits to identify cell expressing active caspases. The goal of the present work was to investigate whether exists differences between percentages of sperm labeled with distinct...
Introduction: The nuclear enzyme poly (ADP-ribose) polymerase-1 (PARP-1) is essential for the repair of single-strand breaks in DNA by means of base excision repair and represents an important target in the therapy cancer. Inhibitors of PARP-1 have been shown to potentiate the cytotoxic effects of ionizing radiation and chemotherapeutic agents...