El síndrome de Intestino Irritable (SII) es un trastorno de la interacción intestino-cerebro (TIIC) que se caracteriza por la presencia de dolor abdominal asociado con cambios del hábito intestinal. Con base en lo anterior, se clasifica en los subtipos con predominio en estreñimiento (SII-E), predominio de diarrea (SII-D), alternancia entre...
Osteosarcopenic obesity (OSO) has been associated with immobility, falls, fractures, and other dysfunctions, which could increase mortality risk. However, its etiology remains unknown. Recent studies revealed that sedentarism, fat gain, and epigenetic regulators are critical in its development. One effective intervention to prevent and treat OSO is exercise. Therefore, in...
In aging, changes in body composition occur even without significant changes in the body mass index (BMI), which generate a decrease in strength and mobility in the elderly, conditioning them to sedentary lifestyle. The increase in body fat, the decrease in muscle mass and bone mineral density lead to the...
Sarcopenia is a syndrome characterized by the generalized and progressive loss of skeletal muscle mass and strength associated with aging. A sedentary lifestyle contributes to this condition, exacerbating and becoming a vicious cycle between difficulty in performing daily life tasks and disability, leading to total dependence and even death. Exercise...
Aging is a multifactorial phenomenon that involves the different levels of biological organization, leading to the old age frailty and dysfunction, which eventually culminates in pathologies and death. The brain is a very susceptible tissue due to its high oxygenic need and low antioxidant capacity generating neurodegenerative diseases. Nrf2 is...
Liver plays an unique role as metabolic center that carries out must of xenobiotics and drugs biotransformation and detoxification. Lipopolysaccharide (LPS), which localizes in the gram-negative bacterial external membrane, is a known immunogen that induces inflammatory responses and enhances reactive oxygen species (ROS) generation. Host response to LPS includes the...
With the increase in life expectancy in our country, as well as in the rest of the world, cardiovascular and neurodegenerative diseases have increased to a great extent. However, treatments indicated have advanced notably, the progression of these diseases persists, limiting the patients quality and life expectancy. In this study,...
La senescencia es un fenómeno que se caracteriza por la detención permanente de la proliferación en respuesta a un daño o estrés, y por eso principalmente ha sido relacionado principalmente con el envejecimiento y enfermedades asociadas a este. Sin embargo, recientemente se ha demostrado su participación en otros procesos fisiológicos...
Children malnutrition is considered a severe public health problem, so much so that in 1956 the first classification was created to establish the different degrees of malnutrition. In the 1960s, studies were begun on the antioxidant defense systems and the concentration of micronutrients in malnourished children at a systemic level...