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1. Efecto de la nicotinamida como inhibidor de la poli (ADP-ribosa) polimerasa en cáncer de mama deficiente de BRCA1

Beschreibung:: Introduction: The nuclear enzyme poly (ADP-ribose) polymerase-1 (PARP-1) is essential for the repair of single-strand breaks in DNA by means of base excision repair and represents an important target in the therapy cancer. Inhibitors of PARP-1 have been shown to potentiate the cytotoxic effects of ionizing radiation and chemotherapeutic agents...
Fach:: Enzimas, Breast -- Cancer, Enzymes, NAD-ADP-ribosyltransferase, Biología experimental, Biology, Experimental, Poli ADP ribosa polimerasa, and Mamas -- Cáncer
Schöpfer:: Domínguez Gómez, María Guadalupe Isabel
Mitwirkender:: García López, Patricia, Damián Matzumura, Pablo Gustavo, Gutiérrez Ruiz, María Concepción, Dueñas González, Alfonso, Gómez Quiroz, Luis Enrique, and Aréchaga Ocampo, Elena
Herausgeber:: Universidad Autónoma Metropolitana
Posgrado:: Doctorado en Biologia Experimental
Sprache:: spa
Año de publicación:: 2014
Rechte:: Acceso Abierto
Lizenz:: Atribucion-NoComercial 4.0 Internacional (CC BY-NC 4.0)
Tipo de Recurso:: info:eu-repo/semantics/doctoralThesis
Identifikator:: https://doi.org/10.24275/uami.wp988j98c