El factor de crecimiento de hepatocitos (HGF) y su receptor c-Met protegen contra el daño celular provocado por el estrés oxidante mediante la inducción de proteínas antiapoptóticas y antioxidantes. Nrf2 es un factor de transcripción que regula positivamente la expresión de genes antioxidantes en el hígado, sin embargo, ahora se...
Cholestasis is a condition associated with a full or partial reduction in the bile flow that reaches the duodenum, caused either by a mechanical blockage impeding the normal flow of bile through the intra an d extrahepatic bile ducts (obstructive cholestasis) or due to alterations on the hepatocellular or ductular...
NAFLD is the most common chronic liver disease worldwide, affecting between 25 and 30% of people. The cholesterol overloading in the liver has a toxic effect mainly mediated by ROS generation and is involved in the induction and progression from NAFLD through NASH. Recently, major advance in understanding the NAFLD...