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Descrição: | Introduction: The nuclear enzyme poly (ADP-ribose) polymerase-1 (PARP-1) is essential for the repair of single-strand breaks in DNA by means of base excision repair and represents an important target in the therapy cancer. Inhibitors of PARP-1 have been shown to potentiate the cytotoxic effects of ionizing radiation and chemotherapeutic agents... |
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Sujeito: | Enzimas, Breast -- Cancer, Enzymes, NAD-ADP-ribosyltransferase, Biología experimental, Biology, Experimental, Poli ADP ribosa polimerasa, and Mamas -- Cáncer |
O Criador: | Domínguez Gómez, María Guadalupe Isabel |
Contribuinte: | García López, Patricia, Damián Matzumura, Pablo Gustavo, Gutiérrez Ruiz, María Concepción, Dueñas González, Alfonso, Gómez Quiroz, Luis Enrique, and Aréchaga Ocampo, Elena |
Editor: | Universidad Autónoma Metropolitana |
Posgrado: | Doctorado en Biologia Experimental |
Língua: | spa |
Año de publicación: | 2014 |
Direitos: | Acceso Abierto |
Licença: | Atribucion-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
Tipo de Recurso: | info:eu-repo/semantics/doctoralThesis |
Identificador: | https://doi.org/10.24275/uami.wp988j98c |